How The body Regulate Testosterone and sperm Production
the Brains Has two parts that are relevant to the production of testosterone and sperm cells in the testies, those are the hypotalomous and the pituiritary, the hypotalomous produces gonadotropin – releasin hormone which in turn signals to the pituitary to produces lutenizing hormones and follicle stimulating hormones also called lh and fsh,
lh signals to the latex cells in the testes to produces testoserone in the testes and thereby lh increases testosterone in the testes and begins the cycle of spermatogenesis, fsh on the other hand signals to the sertoli cells in the testes to mature and differentiate these sperm being created,
What should be used as post cycle therapy for steroids
The tools That should be used directly relate to stimulating the effects of lh and fsh in the body, what that means is instead of going into the brain to try to rapair the production from the pituitary we’re stimulating the biological function of lh and fsh in the body such that the testes can responde to those signals so specifically the first tool that we’ll talk about is human chorionic gonandotropin that is hcg.
Hcg is a biomarker found in the urine of pregnant woman and originally has a pharmaceutical tool it was used and develop in the urine of pregnant females, later recombinant versions where created that thankfully show equal efficaciousness as the natural derived product.
now what hcg does its structually is very similar to both lh and fsh however the small changes in its structure from lh and fsh allow it to be first of all to have a longer half-life than lh, it has 36 hours half-life as compared to 30 minute half-life and second of all and quite important it has greater affinity for the lh receptor then even lh does, so what happens is when hcg is injected subcutaneusly as a man it stimulates the effect of lh. thereby signaling to the testes to begin intratrsticular testosterone production, and this begins the stages of sperm developments.
Now human menopausal gonadotropin which is also called hmg its also derived from post menopausal woman and originally was derived directly from them, the the recombinant version were created that seemed to be effective, hmg has a large majority of it sort of useless urinary proteins and a small part of it has fsh lh and hcg and it was mainly used for that portion of it that had fsh tring to signals to the body to replace the signal from the pituritary that involves fsh to signals to the testes to mature and differentiate the sperm that has been created, now what happend was lately in the last 10 years there was development that led to whats called recombinant fsh wich goes directly to the subject that we really want to deal with while hmg has a little bit of fsh in it, recombinant fsh is entirely produced of fsh, fsh is basically the thing that we really tryng to get to, now tnere are no studies that compare fsh efficasciousness to hmg however there are studies that analize the efficasciousness of recombinant fsh itsel and it seems very effective at the task that we want to accomplish,
hcg administered alone will stimulate intratesticular testosterone production and that will lead to sperm being created in the testes, so hcg can yeld not only testicular production of testosterone but also fertility on its own, in fact it sometimes does this in some studies up to 70 percent of the people, however fsh recombinant fsh wich is the superior version of hmg , cannot do this on its own and additionaly hcg is effect on fertility is definetly enhanced when its combined fsh, so what we can tell from this is that if you can only pick one then pick hcg but if you can pick two it is definetly better and pick a recombinant fsh wich is called ,
thats is the lowdown on what hmg and hcg are, now on terms of efficacios dosing from clinical studies hcg has been used in quite different amount, from as low as 1000 to 5000 iu twice a week, the same dosing schedule is used for hmg however the units used are beetwen 75 iu to 400 iu , you should look as this substances working togheter and if you can only prefer 1 pick hcg and if you can get both you should pick hcg and recombinant fsh, and if you cant get recombinat fsh than pick hmg,
you should keep in mind that hmg is quite difficular to find and hcg are both hard to find of good quality like we have here, a long duration of treatment is absolutrly neccessary to get a proper restoration of function, usually pct protocol involve month long hcg, and are not optimal as they are not truly efficascious if you need to recover after long time on steroids, now in the world of aas is that most people who use aas for significant amount of time basically stay on aas for the rest of their lives, and its very rare that you find somebody that used aas for sit like a over a year in a row or two years that completely goes of it, because of its reason there is not that much known from empirical practice within the comunites about what it really takes to recover your testosterone production and your fertility long term, so this is why you should be aware that short pct protocol are not optimal to restore good amount of function, and if you really want to recover optimally you should use 2-3 months of protocol at the dosages discusses before depending on how much and for how many times have you use steroids.
Citation
1 https://pubmed.ncbi.nlm.nih.gov/12470572/
2 https://pubmed.ncbi.nlm.nih.gov/20846363/
3 https://pubmed.ncbi.nlm.nih.gov/1516981/
4 https://academic.oup.com/jcem/article-abstract/77/6/1545/2650302?redirectedFrom=PDF
4 https://pubmed.ncbi.nlm.nih.gov/25271205/
6 https://pubmed.ncbi.nlm.nih.gov/12801577/