Hilma Biocare – TB 500 Thymosin Beta 4




TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all
human and animal cells. The main purpose of this peptide is to promote healing. It also
promotes creation of new blood and muscle cells. The healing effects of TB-500 have been
observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is
naturally produced in higher concentration where tissue has been damaged. This peptide is
also a very potent anti-inflammatory agent. TB-500 is different from other repair factors
(growth hormone, IGF-1), because it promotes endothelial and keratinocyte migration. It also
does not bind to the extracellular matrix and has a very low molecular weight. Because of
this it can travel long distances through the tissues in the human body.One of TB-500 key
mechanisms of action is its ability to regulate the cell-building protein – Actin. Of the
thousands of proteins present within human cells, actin represents roughly 10% of the total.
It is thus a vital component of cell structure and movement. Thymosin Beta-4 is a protein
which consists of 43 amino acids and is encoded by the gene TMSB4X in the human body. It
has been studied in numerous clinical trials. Research has shown that if the thymosin beta-4
peptide is used after a heart attack it can reactivate cardiac progenitor cells to repair
damaged heart tissue Thymosin beta-4 has a very large molecule. In fact, it is so large that it
cannot fit entirely into the receptor. Different sections of the molecule have different activities.
TB-500 is the part of thymosin beta-4 hormone which promotes the most useful effects
(overall healing, repair, new blood and muscle cells). For medical applications it is more
practical to use the TB-500 instead of the entire Thymosin Beta-4 protein.


Being used in veterinary and human medicine, the TV-500 shows the following effects:

• Accelerates the recovery of muscles (including the heart muscle), ligaments, joints and
skin. It has a pronounced reparative potential on many tissues.
• Anti-inflammatory effect.
• Angiogenesis: the growth of new vessels in the muscles, which improves their nutrition.
• Protects and restores the nervous system.
• Stimulates the secretion of luteinizing hormone, and as a result of testosterone.
• Increases tissue sensitivity to the anabolic hormone insulin.
• Increases joint mobility and ligament distensibility.
• TB-500 is a cardioprotector that reduces the risk of myocardial infarction, restores
myocardium. It has a regenerative property even with myocardial ischemia.


Plain sterile water is the most suitable diluent for TB-500. Alternatively it can be reconstituted
with sterile saline (0.9% NaCl) or sterile bacteriostatic water (0.9% sodium chloride). The
insulin type syringe with 100 markings on the side should be used. Pull 1 ml of water into the
syringe and inject it into the vial with powder. You should never shake the vial when mixing.
You should not inject the water directly into the powder with force, but rather let it gently slide
down the inside of the vial. If it bubbles up, you should put the vial in the refrigerator and
leave it there for about 15-30 minutes. The bubbles will be gone by then. You should then
gently rotate the vial between your fingers until all of the powder has dissolved (it takes
about 3-4 minutes). The tb-500 has a systematic effect regardless of where it is injected. It
can be injected subcutaneously (stomach fat) or intramuscularly (shoulders, thighs,
buttocks). Injections should be given in different sites each time. Prior to injecting clean the
injection spot with an alcohol swab. Make sure there are no air bubbles in the syringe. For
subcutaneous injection fully insert the needle at an 45 degree angle, for intramuscular insert
it at 90 degrees angle.


The most recommended dose ofnu TB-500 is 2.0-2.5 mg of TB-5002 twice a week for
approximately 4-6 weeks. After obtaining the desired result and healing the injuries, the M
patient can make 1-2 injections once a month.


A randomized controlled trial did not reveal toxic and serious side effects, even at high
dosages. However, it is not recommended to exceed the indicated dosage.


Store under 2…8°C. Do not freeze. Protect from direct sunlight.
Manufactured by: Hilma Biocare
Distributed by: Rein Farmacie, Belgium


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